Researchers have found a way to significantly reduce atherosclerosis that does not involve treating cholesterol, blood pressure or insulin resistance.
And, as for those that don’t know, atherosclerosis is the process through which fatty substances, such as cholesterol and cellular waste products accumulate in the lining of arteries and….it is those buildups, called plaques which reduce blood flow through the artery and can contribute to heart attack, stroke and even gangrene.
- In short, atherosclerosis is bad news.
- It is also big business for the drub companies.
- And as a result, this research is big news in the medical community.
In the study, the research team inhibited atherosclerosis in mice by interfering with production of a substance called fatty acid synthase.
This enzyme converts dietary sugars into fatty acids in the liver, where it plays an important role in energy metabolism.
It is also involved in the creation of atherosclerosis.
â€œThe plaques that clog arteries contain large amounts of fatty acids,â€ says senior investigator Clay F. Semenkovich, MD. In this study, â€œwe engineered mice that are unable to make fatty acid synthase in one of the major cell types (the macrophages) that contribute to plaque formation”.
“On a standard Western diet high in fat, the mice had less atherosclerosis than their normal littermates.”
So, what does this mean to you?
According to the researchers, these mouse experiments suggest targeting fatty acid synthase in macrophages may provide a potential treatment strategy for humans.
The researchers identified factors in the fatty acid pathway that seem to be capable of preventing plaques from blocking arteries in mice. He says those substances â€“ LXR-alpha and ABCA1 â€“ eventually may become drug targets.
â€œIt may be possible, for example, to take macrophages out of humans, inhibit fatty acid synthase in those cells, and then infuse the macrophages back into the same person,â€ he says. â€œFrom what weâ€™ve observed in mice, we would hypothesize that approach might prevent or interfere with plaque buildup in people.”
aka CARBS aka BREAD aka SODA aka PIZZA aka MOCHA FRAPPUCHINOS aka DOUBLE CHOCOLATE GOOEY BUTTER CAKE,Â etc…
Damn…now I’m getting hungry.
Time for a grilled cheese sandwich and my experimental synthase inhibitor.